Table 5.

Ten most upregulated and downregulated GO classifications for carcinomas versus adjacent nontumor tissues

Biological process classification	No. of genes	Cellular component classification	No. of genes	Molecular function classification	No. of genes	Regulation
Cellular process	436	Cytoplasm	296	Protein binding	247	Up
Biological regulation	309	Cytoplasmic part	237	Receptor binding	54	Up
Primary metabolic process	296	Extracellular region	102	Structural molecule activity	35	Up
Regulation of biological process	290	Membrane-enclosed lumen	96	Carbohydrate binding	21	Up
Regulation of cellular process	276	Organelle lumen	94	Pattern binding	16	Up
Macromolecule metabolic process	247	Cytosol	86	Polysaccharide binding	16	Up
Response to stimulus	241	Plasma membrane part	79	Glycosaminoglycan binding	15	Up
Multicellular organismal process	225	Extracellular region part	70	Chromatin binding	15	Up
Developmental process	192	Endoplasmic reticulum	57	G-protein coupled receptor binding	14	Up
Cellular response to stimulus	189	Cell projection	47	Protein complex binding	14	Up
Cellular response to stimulus	183	Cell part	508	Binding	426	Down
Cell communication	179	Cell	508	Protein binding	255	Down
Signaling	176	Cytoplasm	341	Catalytic activity	215	Down
Signal transduction	160	Membrane	286	Transferase activity	76	Down
Positive regulation of biological process	129	Cytoplasmic part	255	Oxidoreductase activity	44	Down
Positive regulation of cellular process	121	Cell periphery	185	Enzyme regulator activity	44	Down
Response to chemical stimulus	110	Plasma membrane	182	Calcium ion binding	38	Down
Small molecule metabolic process	108	Extracellular region	106	Protein dimerization activity	36	Down
Regulation of response to stimulus	93	Plasma membrane part	101	Identical protein binding	35	Down
Catabolic process	84	Cytosol	90	Protein homodimerization activity	27	Down