Table 1.
Characteristics of the investigated studies
| Author | Year | Country | Region | Study design | Genotyping | T2DM | Control | P HWE | Sample size (T2DM/Control) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| TT | AT | AA | TT | AT | AA | ||||||||
| Alharbi [9] | 2014 | Saudi | Asia | Case-control | TaqMan | 37 | 170 | 220 | 29 | 171 | 260 | 0.90 | 887 (427/460) |
| Bu [19] | 2011 | USA | North America | Case-control | PCR-RFLP | 163 | 107 | 23 | 187 | 94 | 17 | 0.26 | 591 (293/298) |
| Tavridou [11] | 2009 | Greek | Europe | Case-control | PCR-RFLP | 24 | 104 | 114 | 13 | 71 | 104 | 0.85 | 430 (242/188) |
| Fisher [14] | 2006 | Germany | Europe | Case-control | pyrosequencing | 14 | 84 | 93 | 37 | 162 | 183 | 0.89 | 573 (191/382) |
| Vimaleswaran [12] | 2006 | India | Asia | Case-control | PCR-RFLP & Direct sequencing | 73 | 317 | 383 | 64 | 353 | 482 | 0.95 | 1672 (773/899) |
| Tahvanainen [20] | 2000 | Mix | Europe | Case-control | TaqMan | 18 | 146 | 166 | 27 | 125 | 184 | 0.38 | 666 (330/336) |
| Hayakawa [21] | 1999 | Japan | Asia | Case-control | PCR-RFLP | 4 | 5 | 6 | 28 | 86 | 91 | 0.29 | 220 (15/205) |
| Lei [22] | 1999 | USA | North America | Case-control | PCR-RFLP | 12 | 119 | 190 | 48 | 357 | 587 | 0.50 | 1313 (321/992) |
| Ito [23] | 1999 | Japan | Asia | Case-control | PCR-RFLP | 23 | 76 | 51 | 22 | 62 | 63 | 0.30 | 297 (150/147) |
| Xiang [24] | 1999 | China | Asia | Case-control | PCR-RFLP | 6 | 30 | 25 | 9 | 53 | 54 | 0.41 | 177 (61/116) |
| Yamada [25] | 1997 | Japan | Asia | Case-control | PCR-RFLP | 5 | 13 | 14 | 26 | 115 | 96 | 0.33 | 269 (32/237) |
PCR: polymerase chain reaction; RFLP: restriction fragment length polymorphism; Mix: Baltic, United Kingdom, middle and southern Europe. HWE: P value of Hardy-Weinberg equilibrium of controls.