The mRNA expression (A) of osteoprotegerin (OPG), receptor activator of nuclear factor-κB ligand (RANKL) and the quantitative ratio of OPG/RANKL (B). Values are expressed as mean ± SEM, n = 10 in each group. Δ P < 0.05, ΔΔP < 0.01, versus Sham (4 week); **P < 0.01, versus Sham (8 week); #P < 0.05, versus OVX (4 week).