mRNA expression of the bone metabolism regulators, transforming growth factor β (TGF-β), carbonic anhydrase II (CAII), matrix metalloproteinase (MMP)-9 in the proximal tibia (A) and densitometric quantification (B). Values are expressed as mean ± SEM, n = 10 in each group. ΔP < 0.05, versus Sham (4 week); *P < 0.05, **P < 0.01, versus Sham (8 week).