Table 2.

Basic parameters and biomarkers in serum and urine

	Sham	OVX
BW (g)
4 week	258 ± 11	283 ± 9Δ
8 week	275 ± 15	321 ± 10**,##
Serum Ca (mg/dL)
4 week	10.05 ± 0.61	10.72 ± 0.28
8 week	10.65 ± 0.58	9.05 ± 0.49*,#
Urine Ca/Cre (mg/mg)
4 week	0.036 ± 0.002	0.048 ± 0.005
8 week	0.042 ± 0.005	0.089 ± 0.008**,##
Serum intact PTH (pg/mL)
4 week	106 ± 6.9	125 ± 7.2Δ
8 week	96 ± 6.9	137 ± 10.3*
Serum FGF-23 (pg/mL)
4 week	368 ± 11.8	258.8 ± 6.4Δ
8 week	408 ± 15.2	175.1 ± 10.5**,#
Serum TRACP-5b (U/L)
4 week	2.47 ± 0.16	2.94 ± 0.09Δ
8 week	2.69 ± 0.13	3.14 ± 0.11*

Values are expressed as mean ± SEM, n = 10 in each group.

^Δ P < 0.05, versus Sham (4 week);

^* P < 0.05, versus Sham (8 week);

^** P < 0.001, versus Sham (8 week);

^# P < 0.05, versus OVX (4 week);

^## P < 0.01, versus OVX (4 week).

BW, body weight; Ca, calcium; Cre, creatinine; PTH, parathyroid hormone; FGF-23, fibroblast growth factor-23; TRACP-5b, tartrate resistant acid phosphatase-5b.