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. 2015 Apr 15;8(4):5862–5868.

Table 1.

Study characteristics

Study (year) Country Ethnicity Genotyping method SNP ID Gender (M/F) Age (mean ± SD, a) Sample size Refractive degree (diopter) Axial length (mm) HWE

Cases Controls Cases Controls Cases Controls Cases Controls Cases Controls
Zhang et al. (2011) China Asian Dye terminator-based SNaPshot rs2075555 317/380 352/411 34.3 ± 11.9 54.5 ± 9.2 697 762 ≤ -6.00 > -1.0 ≥ 26 NA rs2075555: 0.09
rs2269336 rs2269336: 0.05
Vatavuk et al. (2009) Croatia Caucasian HumanHap Genotyping BeadChip rs2075555 4/15 NA NA NA 19 925 ≤ -6.00 NA NA NA rs2075555: 0.922
Nakanisbi et al. (2009) Japan Asian TaqMan rs2075555 134/293 194/226 57.6 ± 14.1 44.3 ± 12.1 427 420 ≤ -5.00 NA ≥ 26.5 NA rs2075555: 0.234
rs2269336 rs2269336: 0.655
Liang et al. (2007) Taiwan Asian TaqMan rs2075555 471/0 623/0 18-25 NA 471 623 ≤ -6.0 D in one eye and ≤ –4.0 D in the other eye ≥ -1.5 NA NA rs2075555: 0.459
Inamori et al. (2007) Japan Asian PCR rs2075555 131/199 131/199 37.82 ± 11.97 37.82 ± 11.97 330 330 ≤ -9.25 NA 27.78 ± 1.30 NA rs2075555: 0.663
rs2269336 rs2269336: 0.016

PCR: Polymerase chain reaction; RFLP: Restriction fragment length polymorphism; NA: Not applicable; HWE: Hardy-Weinberg equilibrium.