Table 1.
Study (year) | Country | Ethnicity | Genotyping method | SNP ID | Gender (M/F) | Age (mean ± SD, a) | Sample size | Refractive degree (diopter) | Axial length (mm) | HWE | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||
Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | ||||||
Zhang et al. (2011) | China | Asian | Dye terminator-based SNaPshot | rs2075555 | 317/380 | 352/411 | 34.3 ± 11.9 | 54.5 ± 9.2 | 697 | 762 | ≤ -6.00 | > -1.0 | ≥ 26 | NA | rs2075555: 0.09 |
rs2269336 | rs2269336: 0.05 | ||||||||||||||
Vatavuk et al. (2009) | Croatia | Caucasian | HumanHap Genotyping BeadChip | rs2075555 | 4/15 | NA | NA | NA | 19 | 925 | ≤ -6.00 | NA | NA | NA | rs2075555: 0.922 |
Nakanisbi et al. (2009) | Japan | Asian | TaqMan | rs2075555 | 134/293 | 194/226 | 57.6 ± 14.1 | 44.3 ± 12.1 | 427 | 420 | ≤ -5.00 | NA | ≥ 26.5 | NA | rs2075555: 0.234 |
rs2269336 | rs2269336: 0.655 | ||||||||||||||
Liang et al. (2007) | Taiwan | Asian | TaqMan | rs2075555 | 471/0 | 623/0 | 18-25 | NA | 471 | 623 | ≤ -6.0 D in one eye and ≤ –4.0 D in the other eye | ≥ -1.5 | NA | NA | rs2075555: 0.459 |
Inamori et al. (2007) | Japan | Asian | PCR | rs2075555 | 131/199 | 131/199 | 37.82 ± 11.97 | 37.82 ± 11.97 | 330 | 330 | ≤ -9.25 | NA | 27.78 ± 1.30 | NA | rs2075555: 0.663 |
rs2269336 | rs2269336: 0.016 |
PCR: Polymerase chain reaction; RFLP: Restriction fragment length polymorphism; NA: Not applicable; HWE: Hardy-Weinberg equilibrium.