Table 2.
Meta-analysis of COL1A1 rs2075555 and rs2269336 and high myopia risk
| SNPs | Models tested | Number of studies | Pooled OR (95% CL) | P | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Q | PQ | I 2, % | |||||
| rs2075555 | Dominant model | 5 | 0.86 (0.74, 0.99) | 0.037 | 4.23 | 0.376 | 5.3 |
| Recessive model | 5 | 0.90 (0.77, 1.06) | 0.197 | 3.88 | 0.422 | 0 | |
| Homozygote | 5 | 0.79 (0.64, 0.97) | 0.024 | 5.26 | 0.261 | 24.0 | |
| Heterozygote | 5 | 0.87 (0.75, 1.02) | 0.076 | 2.79 | 0.593 | 0 | |
| rs2269336 | Dominant model | 3 | 0.88 (0.75, 1.03) | 0.115 | 3.61 | 0.164 | 44.6 |
| Recessive model | 3 | 1.26 (1.05, 1.50) | 0.012 | 4.19 | 0.123 | 52.2 | |
| Homozygote | 3 | 1.13 (0.81, 1.59) | 0.477 | 4.79 | 0.091 | 58.2 | |
| Heterozygote | 3 | 0.81 (0.69, 0.96) | 0.016 | 2.10 | 0.351 | 4.6 | |
“A”, major allele; “a”, minor allele; dominant model, aa + Aa vs. AA; recessive model, aa vs. AA + Aa; homozygote comparison, aa vs. AA; heterozygote, Aa vs. AA.