MTT assay was used to determine the effects of increasing doses of HSYA on LPS-induced VSMCs proliferation. In LPS group, VSMCs were treated with LPS (20 μg/ml) for 24 h. In LPS + HSYA group, VSMCs were treated with LPS (20 μg/ml) and HSYA (0.1 μM, 1μM, 10μM and 100 μM) for 24 h, respectively. VSMCs without any treatment were used as controls. **P<0.01; ns means no significant. LPS: lipopolysaccharide; HSYA: Hydroxysafflor Yellow A.