Table 3.
Frequency distribution of CYP11B2 -344C/T genotype and allele
| Han | Kazak | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| Rs1799998 | Control, n (%) | AF n (%) | P value | Control, n (%) | AF n (%) | P value |
| Genotype | ||||||
| CC | 65 (15.6) | 9 (4.4) | 116 (37.8) | 50 (32.1) | ||
| CT | 223 (53.3) | 90 (44.3) | 158 (51.5) | 86 (55.1) | ||
| TT | 130 (31.1) | 104 (51.2) | <0.001* | 33 (10.7) | 20 (12.8) | 0.449 |
| Dominant model | ||||||
| CC | 65 (15.6) | 9 (4.4) | 116 (37.8) | 50 (32.1) | ||
| CT + TT | 353 (84.4) | 194 (95.6) | 0.133 | 191 (62.2) | 106 (67.9) | <0.001* |
| Recessive model | ||||||
| TT | 130 (31.1) | 104 (51.2) | 33 (10.7) | 20 (12.8) | ||
| CT + CC | 288 (68.9) | 99 (48.8) | 0.538 | 274 (89.3) | 136 (87.2) | <0.001* |
| Co-additive model | ||||||
| CT | 223 (53.3) | 90 (44.3) | 158 (51.5) | 86 (55.1) | ||
| CC + TT | 195 (46.7) | 137 (55.7) | 0.001* | 149 (48.5) | 70 (48.5) | 0.259 |
| Allele frequency | ||||||
| C | 353 (42.2) | 108 (26.6) | 390 (63.5) | 186 (59.6) | ||
| T | 483 (57.8) | 298 (73.4) | <0.001* | 224 (36.5) | 126 (40.4) | 0.247 |
*
indicated significant difference compared to control.