[Table/Fig-1]:
Characteristics of case reports of nms coexisting with primary hypothyroidism
| Author | Age | Diagnosis | Offending Agent | Thyroid Levels | NMS Finding | Risk Factors | Treatment |
|---|---|---|---|---|---|---|---|
| Moore 1990 | 55 F | Personality Change Encephalopathy | Thioridazine 50 mg Several doses | T4- 40 nmol/l (50-150) TSH- 50mU/L normal <(7.4) | CPK 12,360 U/I (normal <175) Fever 41ºC Rigidity drowsy | Organic brain syndrome | Oral L-thyroxine Iv fluid cooling |
| Moore 1990 | 32 F | Obsessive Compulsive Disorder | Thioridazine 50mg, Haloperidol 10 mg (one day) | T4-14.4 pmol/l (11-22) TSH(70IU/L) | Fever 38.5ºC Rigidity CPK>2000 Altered Sensorium | agitation | Cooling Dantrolene Thyroxine .1mg oral |
| Hatch 2001 | 54 M | Alzheimer’s disease Hypothyroidism | Quitiapine 50mg (2days) | NA | CPK not done Fever Altered sensorium Rigidity tremors | encephalopathy | L-thyroxine 88 μg/day Lorazepam |
| Kawajiri 2002 | 59 M | Parkinson’s Disease Depression | L-DOPA Amitriptyline Etizolam (several days) | T4 - 0.6 ng/dl (0.9-2.3) TSH -108.7 mU/ml (0.2-4.2) | Fever/altered sensorium/high CPK rigidity | Withdrawal of Benzodiazapine Organic brain syndrome | Bromocriptine Dantrolene |
| Dixit 2015 | 40 F | Schizophrenia | Olanzapine 20 mg (several months), Amisulpride 200mg (5days) | T4-1.40 mcg/dl (5.-12.45) TSH 165.85 mIU/L (.55–4.78) | Fever, altered sensorium CPK-3745 IU/l, | Polydrug therapy Metabolic encephalopathy | Iv L-thyroxine Ionotropes Iv Hydrocortisone Oral thyroxine Bromocriptine |