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Productive viral replication in the macrophage in the dorsal nerve root and dorsal root ganglion (DRG) of SIV-infected macaques. A: Dorsal nerve root of animal A11 with abundant SIVp28 (brown) immunoreactivity and multinucleated giant cells (MNGCs) in SIV-infected rhesus macaque. B: DRG of animal A06 with abundant SIVp28 (brown) immunoreactivity and a MNGC. C: DRG of animal A05 with in situ hybridization identifying SIV RNA+ cells (blue).
