Table 3.

Summary of serious adverse events experienced by patients receiving P276-00.

System Organ Class a	Preferred Term a	Grade a	Relationship to Study Drug	Action Taken with Study Drug	Other Action Taken	Outcome
Investigations	Blood creatinine increased	2	None/Unrelated	Discontinued	Hospitalization	Ongoing
Respiratory, thoracic and mediastinal disorders	Dyspnea	3	None/Unrelated	None	None	Ongoing
Cardiac disorders	Atrial fibrillation	3	None/Unrelated	None	Hospitalization	Complete Recovery
Infections and infestations	Herpes zoster	3	Possible	Discontinued	Hospitalization	Complete Recovery
Blood and lymphatic system disorders	Thrombocytopenia	4	Possible	None	Transfusion	Ongoing
General disorders and administration site conditions	Disease progression	5	Unlikely	None	Medication Given	Death
General disorders and administration site conditions	Disease progression	5	None/Unrelated	Discontinued	None	Death

^aTerminology and definitions are taken from the National Cancer Institute's Common Terminology Criteria of Adverse Events.