Table 1.
Actual CORT levels are presented, but analysis is based on the calculated percent change of basal CORT from PND 31 to PND 41 (pre- to post-CMS). PAE-Non CMS females had a greater % change in basal CORT from PND31-PND41 relative to both (a) Con and (b) PF - Non CMS females (P = 0.043; P = 0.070, respectively), whereas PAE-CMS females showed a marginally lower % change in CORT levels relative to that of (c)Con-CMS females (P = 0.062). On the other hand, Con-CMS females alone showed a significantly higher % change from pre- to post-CMS relative to their (a) Con-Non CMS counterparts (P = 0.005).
Basal Corticosterone (μg/dL) | PND31 | PND41 | N | |
---|---|---|---|---|
Con | Non CMS | 1.61 (± 0.83) | 0.76 (± 2.03) | 17 |
CMS | 1.30 (± 0.83) | 10.60 (± 2.03)*a | 17 | |
PF | Non CMS | 2.49 (± 0.95) | 0.77 (± 2.32)ns | 13 |
CMS | 3.77 (± 0.85) | 6.54 (± 2.09)ns | 16 | |
PAE | Non CMS | 1.32 (± 0.88) | 5.80 (± 2.16)*a†b | 15 |
CMS | 1.79 (± 0.85) | 3.83 (± 2.09)†c | 16 |
significant at P ≤ 0.05;
trend towards difference.
different from Con-Non CMS,
different from PF-Non CMS,
different from Con-CMS.