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. 2015 Jun 29;5:11708. doi: 10.1038/srep11708

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Copyright © 2015, Macmillan Publishers Limited

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(A). The ApoTox-Glo^TM assay in neuronal HT22 cells. Cell viability was decreased but cytotoxicity and caspase-^3/7 activation were increased after treatment with Aβ_1-42 (5 μM) compared with the control treatment. Treatment with osmotin at three different concentrations (0.1, 0.2, or 0.4 μM) significantly reduced the effects of Aβ_1-42, thereby increasing cell viability and decreasing cytotoxicity and caspase-^3/7 activation. (B) The ApoTox-Glo^TM assay in primary hippocampal neuron cultures from GD 17.5 rat fetuses. Cell viability was decreased but cytotoxicity and caspase-^3/7 activation were increased after Aβ_1-42 (5 μM) treatment compared with the control treatment. Treatment with osmotin at three different concentrations (0.1, 0.2, or 0.4 μM) significantly reduced the effects of Aβ_1-42, thereby increasing cell viability and decreasing cytotoxicity and caspase-^3/7 activation. #significantly different from the control; *significantly different from the Aβ_1-42-treated mice. Ns = not significant compared with the Aβ_1-42-treated mice. n = 3 per experiment.