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. 2015 Jul;25(7):937–947. doi: 10.1101/gr.191247.115

Figure 4.

Figure 4.

EGL321's chromothripsis translocations. (A) Karyotype of EGL321; red arrows indicate translocation chromosomes. (B) FISH confirms the translocation of the long arm of Chromosome 2 (probe RP11-89P7) to the long arm of Chromosome 10 (10p15.3 control probe CTB-23B11) and the translocation of the long arm of Chromosome 7 (probe RP11-3K23) to the long arm of Chromosome 2 (2p25.3 control probe RP11-71M21). (C) Model of EGL321's rearrangements. Zoomed-in translocation junctions show breakpoints on the derivative chromosomes. (D) Example of parent-of-origin analysis for EGL321. Underlined G is adjacent to a Chromosome 10 breakpoint and is derived from the paternal (P) allele.