Figure 4.

Prevalence of clinical hypogonadism (left) and abnormal glucose tolerance (right) as a function of pancreas and cardiac iron metrics. Low risk patients are defined as having no detectable cardiac iron (T2* > 20 ms) and a pancreas R2* < 100 Hz. Intermediate risk patients have increased pancreas iron (R2* >100 Hz) but no cardiac siderosis. High risk patients have cardiac siderosis (all of them also have pancreas R2* > 100 Hz). Both hypogonadism and diabetes are extremely common in patients with cardiac siderosis, indicating that cardiac iron is a late manifestation of poor non-transferrin-bound iron control. Pancreatic iron deposition, in the absence of cardiac iron overload, also conveys an intermediate risk of both pituitary and pancreatic dysfunction. Figures derived from data presented previously(Noetzli et al, 2012a;Noetzli et al, 2012b). IFG, impaired fasting glucose; IGT, impaired glucose tolerance; DM, diabetes mellitus