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. 2015 Jun 29;5:11685. doi: 10.1038/srep11685

Table 3. Predictive values of plasma hCAP-18 or LL-37 levels* in the diagnosis of SCN.

SCN versusAIN, IN and EN AUC (95% CI) Sensitivity % Specificity % Positive predictive value % Negative predictive Value %
hCAP-18 ELISA 1.00 (1.00 –1.00) 100 98.8 95.8 100
hCAP-18 IB 0.99 (0.98 –1.00) 100 96.6 88.5 100
LL-37 ELISA 0.95 (0.89 –1.00) 73.9 93.7 77.3 92.5

SCN, severe congenital neutropenia; AIN, autoimmune neutropenia; IN, idiopathic neutropenia; EN, ethnic neutropenia; AUC, area under the curve; CI, confidence interval; IB, immunoblotting.

*The diagnostic cut-off values were 14% by immunoblot, 88 ng/ml by hCAP-18 ELISA, and 11 ng/ml by LL-37 ELISA.