Table 3. Predictive values of plasma hCAP-18 or LL-37 levels* in the diagnosis of SCN.
SCN versusAIN, IN and EN | AUC (95% CI) | Sensitivity % | Specificity % | Positive predictive value % | Negative predictive Value % |
---|---|---|---|---|---|
hCAP-18 ELISA | 1.00 (1.00 –1.00) | 100 | 98.8 | 95.8 | 100 |
hCAP-18 IB | 0.99 (0.98 –1.00) | 100 | 96.6 | 88.5 | 100 |
LL-37 ELISA | 0.95 (0.89 –1.00) | 73.9 | 93.7 | 77.3 | 92.5 |
SCN, severe congenital neutropenia; AIN, autoimmune neutropenia; IN, idiopathic neutropenia; EN, ethnic neutropenia; AUC, area under the curve; CI, confidence interval; IB, immunoblotting.
*The diagnostic cut-off values were 14% by immunoblot, 88 ng/ml by hCAP-18 ELISA, and 11 ng/ml by LL-37 ELISA.