Table 1. Genes implicated in Ubl metabolism identified as candidate olaparib sensitivity genes in [8].
The extent of olaparib sensitisation is indicated by the median Z score. Negative Z scores indicate a sensitization effect.
| Gene Symbol | Median Drug EffectZScore | Gene name |
|---|---|---|
| CBLC | −7.67 | Cas-13r-M (murine) ecotropic retroviral transforming sequence c |
| MDM2 | −7.46 | Mdm2 p53 binding protein homolog (mouse) |
| ASB5 | −5.77 | ankyrin repeat and SOCS box containing 5 |
| BRCAI | −4.38 | breast cancer I, early onset |
| SOCS6 | −4.11 | suppressor of cytokine signaling 6 |
| TMEM 189- UBE2V I | −4 | TMEM I 89-UBE2V I readthrough |
| WWP I | −4 | WW domain containing E3 ubiquitin protein ligase 1 |
| FBX03 | −3.99 | F-box protein 3 |
| SUMO I | −3.97 | SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) |
| RLIM | −3.92 | ring finger protein, LIM domain interacting |
| RNFI28 | −3.64 | ring finger protein 128 |
| FBX046 | −3.49 | F-box protein 46 |
| USP38 | −3.43 | ubiquitin specific peptidase 38 |
| UBE2C | −3.41 | ubiquitin-coniugating enzyme E2C |
| BAPI | −3.39 | BRCAI associated protein-1 (ubiquitin carboxy-terminal hydrolase) |
| UBAI | −3.35 | ubiquitin-like modifier activating enzyme I |
| SPOPL | −3.2 | speckle-type POZ protein-like |
| FBX0I 1 | −3.19 | F-box protein 11 |
| UBR7 | −3.18 | ubiquitin protein ligase E3 component n-recognin 7 (putative) |
| 1:13XW4 | −3.14 | F-box and WD repeat domain containing 4 |
| RNFI33 | −3.09 | ring finger protein 133 |
| RNF2 | −3.03 | ring finger protein 2 |
| ATG4C | −3.01 | ATG4 autophagy related 4 homolog C (S. cerevisiae) |
| P1AS I | −3 | protein inhibitor of activated STAT, 1 |
| KLHL2 I | −2.98 | kelch-like 21 (Drosophila) |
| TCEB I | −2.94 | transcription elongation factor 13 (SIM, polypeptide 1 (I 5kDa, elongin C) |
| USP7 | −2.94 | ubiquitin specific peptidase 7 (herpes virus-associated) |
| ITCH | −2.93 | itchy E3 ubiquitin protein ligase homolog (mouse) |
| MALTI | −2.93 | mucosa associated lymphoid tissue lymphoma translocation gene 1 |
| USP I 0 | −2.87 | ubiquitin specific peptidase 10 |
| ZBTB16 | −2.86 | zinc finger and BTB domain containing 16 |
| NEURLIB | −2.8 | neuralized homolog I B (Drosophila) |
| SMURF2 | −2.79 | SMAD specific £3 ubiquitin protein ligase 2 |
| DNAHI2 | −2.73 | dynein, axonemal, heavy chain 12 |
| XIAP | −2.72 | X-linked inhibitor of apoptosis |
| BARDI | −2.71 | BRCAI associated RING domain 1 |
| UBE2R2 | −2.71 | ubiquitin-conjugating enzyme E2R 2 |
| CUL7 | −2.67 | cullin 7 |
| RNF144A | −2.65 | ring finger protein I 44A |
| UBE2G2 | −2.63 | ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) |
| RNF168 | −2.62 | ring finger protein 168 |
| Gene Symbol | Median Drug EffectZScore | Gene name |
|---|---|---|
| RNF41 | −2.61 | ring finger protein 41 |
| SKP2 | −2.6 | S-phase kinase-associated protein 2 (p45) |
| UBE4A | −2.6 | ubiquitination factor E4A (UFD2 homolog, yeast) |
| KLHL36 | −2.56 | kelch-like 36 (Drosophila) |
| HECTD4 | −2.55 | chromosome 12 open reading frame 51 |
| USP8 | −2.55 | ubiquitin specific peptidase 8 |
| BRCC3 | −2.54 | BRCA I /BRCA2-containing complex, subunit 3 |
| CDC27 | −2.51 | cell division cycle 27 homolog (S. cerevisiae) |
| UBOX5 | −2.46 | U-box domain containing 5 |
| UFSP2 | −2.44 | UFM1-specific peptidase 2 |
| ATG4D | −2.42 | ATG4 autophagy related 4 homolog D (S. cerevisiae) |
| WWP2 | −2.34 | WW domain containing E3 ubiquitin protein lipase 2 |
| SHPRH | −2.33 | SNF2 histone linker PHD RING helicase |
| IS015 | −2.3 | ISGIS ubiquitin-like modifier |
| KLHL3 | −2.3 | ketch-like 3 (Drosophila) |
| ATG 10 | −2.29 | ATG 10 autophagy related 10 homolog (S. cerevisiae) |
| ATG4A | −2.28 | ATG4 autophagy related 4 homolog A (S. cerevisiae) |
| TR1M31 | −2.25 | tripartite motif containing 31 |
| ATG7 | −2.22 | ATG7 autophagy related 7 homolog (S. cerevisiae) |
| USP9Y | −2.22 | ubiquitin specific peptidase 9, Y-linked |
| FBXL5 | −2.21 | F-box and leucine-rich repeat protein 5 |
| UBE2EI | −2.21 | ubiquitin-conjugating enzyme E2E I (UBC4/5 homolog, yeast) |
| RINGI | −2.19 | ring finger protein 1 |
| MYCBP2 | −2.16 | MYC binding protein 2 |
| ANAPC1 | −2.15 | anaphase promoting complex subunit I |
| FBXL13 | −2.15 | F-box and leucine-rich repeat protein 13 |
| USP33 | −2.14 | ubiquitin specific peptidase 33 |
| USP42 | −2.12 | ubiquitin specific peptidase 42 |
| ASB 16 | −2.11 | ankyrin repeat and SOCS box containing 16 |
| OTUD713 | −2.11 | OTU domain containing 7B |
| UEVLD | −2.11 | UEV and lactatehnalate dehyrogenase domains |
| FBX027 | −2.1 | F-box protein 27 |
| UBE2O | −2.1 | ubiquitin-conjugating enzyme E20 |
| ASB7 | −2.09 | ankyrin repeat and SOCS box containing 7 |
| FBX040 | −2.09 | F-box protein 40 |
| USP I | −2.09 | ubiquitin specific peptidase 1 |
| NPLOC4 | −2.08 | nuclear protein localization 4 homolog (S. cerevisiae) |
| IlECTD1 | −2.06 | HECT domain containing 1 |
| TRIMS | −2.06 | tripartite motif containing 5 |
| ANAPC4 | −2.04 | anaphase promoting complex subunit 4 |
| CANDI | −2.04 | cullin-associated and neddylation-dissociated 1 |
| BTBD I | −2.03 | BIB (POZ) domain containing 1 |
| FEM IC | −2.03 | fem-I homolog c (C. elegans) |
| LRRC29 | −2.03 | leucine rich repeat containing 29 |
| USP21 | −2.03 | ubiquitin specific peptidase 21 |
| FBX038 | −2.01 | F-box protein 38 |
| DCAF13 | −2 | DDB1 and CUL4 associated factor 13 |
| Gene Symbol | Median Drug EffectZScore | Gene name |
|---|---|---|
| FBXO24 | −2 | F-box protein 24 |
| FEM IA | −1.98 | fern-I homolog a (C. elegans) |
| FBX039 | −1.96 | F-box protein 39 |