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. 2015 Feb 12;6(13):10801–10811. doi: 10.18632/oncotarget.2984

Figure 1. Gonadectomy and life span in female and male mice.

Figure 1

(a) Female PPRE-lucRepTOP™ were gonadectomized (OVX, n = 40) or sham-operated (SHAM, n = 40) at 5 months of age. Each group was randomly subdivided into 4 clusters of 10 animals each to be euthanized at 6, 12, 18 and 22 month of age to evaluate the state of inflammation. Predicted cumulative incidence curves for death by natural causes in SHAM and OVX animals were calculated as described in the methodology section. The risk of death by natural causes was significantly higher in ovx mice compared with sham-operated mice (p < 0.05). (b) Male ERE-LucRepTOP™ in the C57BL/6J background were orchiectomized (n = 40) or sham operated (n = 40) at 5 month of age. 20 animals from each group were euthanized at 6 months and 20 months, respectively. Data are expressed as the mean % survival ± SEM.