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(A) PIM1 expression in HCC cell lines and MIHA. N: normoxia (20% O2) H: hypoxia (1% O2). (B) i) PIM1 protein expression was up-regulated at around 30 minutes and preceded that of HIF-1α in SMMC-7721. ii) Treatment of SMMC-7721 with proteasome inhibitor MG132 in normoxia stabilized PIM1 protein. iii) Treatment with propyl hydroxylase inhibitor DMOG in SMMC-7721 and MHCC-97L also stabilized PIM1 protein.
