Figure 6. CXCR4 knock-down confirmed that the SDF-1α/CXCR4 interaction played a critical role in the radiation-induced invasiveness of H1299 cells.

(A) Western blot analysis of the expression levels of downstream molecules in the SDF-1α/CXCR4 pathway, including pAkt, pERK1/2, MMP-2 and MMP-9, after treatment with irradiation, SDF-1α or a combination of SDF-1α plus irradiation. (B) Western blot analysis of the expression of pAkt, pERK1/2, MMP-2 and MMP-9 after the indicated treatment.