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. 2015 Mar 26;6(13):10908–10923. doi: 10.18632/oncotarget.3434

Figure 2. Metformin (Met) reduces the clinical ovarian tumor score.

Figure 2

At the end of the study, various organs of each mouse from the RD, HED and CRD untreated and Met treated groups were grossly examined for enumeration of visible tumor nodules. Score was stipulated as 0: no nodule; 1: 1 nodule; 2: 2 to 5 nodules and 3: more than 5 nodules observed per organ. Tumor scoring at (A) Peritoneum, (B) Diaphragm, (C) Bowel, (D) Liver, (E) Kidney, and (F) Spleen are shown. ***p < 0.001, **p < 0.01, *p < 0.05, ns = non-significant. CRD, caloric restriction diet; HED, high energy diet; RD, regular diet.