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. 2015 Mar 26;6(13):10908–10923. doi: 10.18632/oncotarget.3434

Figure 3. Metformin (Met) decreases the ovarian tumor growth.

Figure 3

Paraffin tumor sections obtained from the peritoneum (A), diaphragm (B), peritoneum and adipose were stained with hemotoxylin and eosin and visualized under a bright-field (20x) to observe for tumor nodules. Each stained tissue picture is a representative of at least 5 individual mouse sections from each of the RD, HED, CRD and Met treated groups. (D) Representative Ki-67 staining from the ID8 tumors at the peritoneum (200x). Count of positive Ki-67 cells from 5 high powered fields (x400) in 3 different xenografts from each group is presented as bar graph. ***p < 0.001, ns = non-significant. CRD, caloric restriction diet; HED, high energy diet; RD, regular diet; Unt, untreated.