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. 2015 Mar 26;6(13):10908–10923. doi: 10.18632/oncotarget.3434

Figure 4. Metformin (Met) regulates the levels of hormones controlling the energy balance.

Figure 4

Plasma and ascitic fluid collected from ovarian tumor bearing mice (n = 6) on RD, HED, and CRD and Met on day 70 were subjected to enzyme-linked immunosorbent assay to determine the levels of (Ai, ii) IGF-1, (Bi, ii) insulin, (Ci, ii) leptin and (Di, ii) adiponectin. ***p < 0.001, **p < 0.01, *p < 0.05, ns= non-significant. CRD, caloric restriction diet; HED, high energy diet; IGF, insulin growth factor; RD, regular diet.