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. 2015 Mar 26;6(13):10950–10963. doi: 10.18632/oncotarget.3459

Figure 1. BMP7 decreases sphere formation in primary GBM-TIC cultures expressing BMPR1B.

Figure 1

(A) Representative phase-contrast images of the different GBM-TIC cultures used in the study. Scale bar: 100 μm. (B) BMPR1A, BMPR1B, BMPR2 and BMP7 relative mRNA expression levels of the cultures. GAPDH was used as the RT-qPCR housekeeping gene. (C) Quantification of the GBM-TIC culture capacity to form spheres in the presence/absence of 50 ng/mL of BMP7. Cells were seeded at low density in 96-well plates and spheres were counted after 7 days. ***p < 0.001.