Table 4. Altered transcript expression in PTC samples as compared to benign counterparts from the same donors (multinodular goiter cases).
| Gene | P-value (PTC vs benign) | P-value with FDR (PTC vs benign) | Fold change | Total number of samples | Number of samples with expression value > 50 (linear scale) |
|---|---|---|---|---|---|
| Without consideration of clinical aggressiveness | |||||
| CHEK1 | 2.63 × 10−4 | 1.15 × 10−3 | 2.05 | 48 | 47 |
| c-KIT | 2.38 × 10−6 | 2.39 × 10−5 | −3.23 | 48 | 48 |
| c-MET | 2.66 × 10−6 | 2.39 × 10−5 | 2.73 | 48 | 48 |
| TIMP1 | 2.00 × 10−3 | 6.00 × 10−3 | 2.01 | 48 | 48 |
| With consideration of clinical aggressiveness: more aggressive PTC (group II in Table 2) | |||||
| BCL2 | 3.08 × 10−6 | 1.38 × 10−5 | −2.11 | 26 | 26 |
| BMAL1 | 7.30 × 10−4 | 1.64 × 10−3 | 1.93 | 26 | 26 |
| CHEK1 | 1.32 × 10−3 | 2.08 × 10−3 | 2.16 | 26 | 26 |
| c-KIT | 1.59 × 10−6 | 9.63 × 10−6 | −4.25 | 26 | 26 |
| c-MET | 5.64 × 10−11 | 1.02 × 10−9 | 4.55 | 26 | 26 |
| PPARγ | 1.59 × 10−3 | 2.21 × 10−3 | −2.81 | 26 | 25 |
| TG | 1.60 × 10−6 | 9.63 × 10−6 | −3.03 | 26 | 26 |
| TIMP1 | 1.22 × 10−5 | 4.38 × 10−5 | 3.38 | 26 | 26 |