. 2015 Mar 26;6(13):10978–10993. doi: 10.18632/oncotarget.3452

Table 6. BRAF exon 15 mutation analysis.

Group	Case	BRAF exon 15		Histologic diagnosis
Group	Case	PROT	DNA	Histologic diagnosis
PTC samples (Table 1)	1	p.V600E	c.1799T>A	^IClassical PTC, pT1b
	2	WT	WT	^IIClassical PTC, pT3pN0
	3	p.V600E	c.1799T>A	^IIClassical PTC, pT3pN1a
	4	p.V600E	c.1799T>A	^IIClassical PTC, pT3 (m)
	5	p.V600E	c.1799T>A	^IIClassical PTC, pT2pN1a
	6	p.V600E	c.1799T>A	^IIClassical PTC, pT3 (m) pN1
	7	p.V600E	c.1799T>A	^IIClassical PTC, pT1bpN0
	8	p.V600E	c.1799T>A	^IFollicular variant PTC, pT1a pN1b
	9	p.V600E	c.1799T>A	^IIClassical PTC, pT2
	10	p.V600E	c.1799T>A	^IIMixed PTC, pT2
	11	p.V600E	c.1799T>A	^IITall cell PTC, pT3 pN1a
	12	WT	WT	^IITall cell PTC, pT3 pN1a
	13	WT	WT	^IIClassical PTC, pT2
	14	not accessible		^IIClassical PTC, pT3 (m)
	15	p.V600E	c.1799T>A	^IIClassical PTC, pT3 (m) pN1b
	16	p.V600E	c.1799T>A	^IIClassical PTC, pT3 pN1b
	17	p.V600E	c.1799T>A	^IIClassical PTC, pT3 pN0
Multinodular goiter PTC samples (Table 2)	35	WT	WT	^IFollicular variant PTC, pT2 (m)
	37	WT	WT	^IFollicular variant PTC, pT2 (m)
	39	WT	WT	^IFollicular variant PTC, pT2
	41	WT	WT	^IFollicular variant PTC, pT2
	43	WT	WT	^IClassical PTC, pT1b (m)
	45	p.V600E	c.1799T>A	^IIClassical PTC, pT3 pN0
	47	WT	WT	^IIClassical PTC, pT3
	49	p.V600E	c.1799T>A	^IIClassical PTC, pT3
	51	p.V600E	c.1799T>A	^IIClassical PTC, pT3 (m) pN1a
	53	p.V600E	c.1799T>A	^IIClassical PTC, pT3
	55	p.V600_K601>Ep.R603Q	c.1799_1801delTGAWT	^IIClassical PTC, pT2 (m) pN0
	57	WT	WT	^IIClassical PTC, pT3 (m) pN1a
	59	WT	WT	^IFollicular variant PTC, pT2
	61	WT	WT	^IFollicular variant PTC, pT1b
	63	WT	WT	^IFollicular variant PTC, pT1b
	65	WT	WT	^IFollicular variant PTC, pT1b
	67	WT	WT	^IFollicular variant PTC, pT2
	69	WT	WT	^IClassical PTC, pT2
	71	WT	WT	^IIOncocytic PTC, pT2
	73	p.V600E	c.1799T>A	^IIClassical PTC, pT1b
	75	p.V600E	c.1799T>A	^IIFollicular variant PTC, pT3(m) pN1a
	77	WT	WT	^IIClassical PTC, pT1b
	79	p.V600E	c.1799T>A	^IIClassical PTC, pT1b
	81	WT	WT	^IISolid PTC, pT1b

less aggressive PTC

^II

more aggressive PTC

Mutation nomenclature is based on the COSMIC data base (Catalogue of Somatic Mutations in Cancer) Sanger Institute: WT– BRAF wild type; pV600E, pV600_K601>E, p. R603Q – mutation at BRAF protein level; c.1799T>A, c.1799_1801delTGA, c1808G>A – mutation at BRAF nucleotide level.