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. 2015 Mar 12;6(13):11009–11022. doi: 10.18632/oncotarget.3557

Figure 5. TGFβR1 inhibitor abrogated tumor growth inhibition in WT mice more effectively than that in LRG KO mice.

Figure 5

a. growth curves of LLC cells on subcutaneous injection into LRG KO mice or WT mice treated with SB431542 (10 mg/kg/week three times intraperitoneally) or vehicle control (n = 5 for each group). Solid lines represent control vehicle-treated groups and dashed lines represent SB431542-treated groups. b. Tumor weight of each group on day 17 after LLC cell inoculation (n = 5). c. TUNEL staining in LLC tumor sections from LRG KO or WT mice treated with SB431542 or vehicle control. Scale bar = 200 μm. d. Quantitative evaluation of TUNEL-positive cells in LLC tumors (five random fields of five independent tumor sections). Data are presented as mean ± standard error of the mean *P < 0.05, **P < 0.01.