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. 2015 Mar 14;6(13):11047–11060. doi: 10.18632/oncotarget.3567

Figure 2. Preferential CGI hypermethylation at the late precancerous stage in Mdr2-KO liver.

Figure 2

At the late precancerous stage, 78 CGIs were aberrantly methylated in the Mdr2-KO liver compared to Mdr2−/+ control. Thirty of these CGIs were specifically hypermethylated in the precancerous Mdr2-KO liver only, while 27 were also hypermethylated at the embryonic stages of liver development. Hybridization to Agilent CGI microarrays of total liver DNA from the 12-month-old Mdr2-KO and Mdr2−/+ mice; 3 males per group; Z-score for methylation > 0.7.