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. 2015 Mar 14;6(13):11087–11097. doi: 10.18632/oncotarget.3571

Figure 3. Effects of claudin blocking antibodies on cell proliferation, morphology, and tubule formation.

Figure 3

(a) MTT assay was used to assess the effects of different blocking antibodies on the proliferation of HUVEC and MDA-MB-231 cells. HUVEC and MDA-MB-231 cells were plated in 96-well plates. Medium containing claudin-2, -3, -4, -6, -7, or -17 blocking antibodies (1 μg/mL) were added to the 96-well plates. An equivalent volume of mouse IgG1 control antibody was used as a control. Data represent the mean + SD (n=3). *: p < 0.05 compared with controls. (b) HUVEC and MDA-MB-231 cells were also cultured in matrigel. Images were acquired by phase-contrast microscopy at the times indicated.