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. 2015 Mar 14;6(13):11125–11138. doi: 10.18632/oncotarget.3575

Figure 6. In vivo effects of Rab3D on tumor metastasis.

Figure 6

(A-B). Rab3D expression in stably transfected tumor cell lines. (C). Representative images of primary tumors and lung section stained with hematoxilin and eosin in control and Rab3D-MCF-7 xenografts bearing mice (n = 5 mice per group). (D). H & E staining of lung in control and shRab3D-MDA-MB-231 xenografts bearing mice. (E). Immunohistochemical staining images and quantification of EMT-related signaling activation in control and Rab3D-MCF-7 xenografts. Scale bar, 50μm. (F). The level of plasma Hsp90α in nude mice detected by ELISA assay (n = 5 mice per group). (G). The working model for Rab3D-induced tumor cell invasion. In response to hypoxia, intracellular Rab3D is increased and its expression is correlated with tumor malignancy. Rab3D regulates exosomes release and Hsp90α secretion, which promotes EMT and tumor metastasis. eHsp90α indicates extracellular Hsp90α.