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. 2015 Mar 20;6(13):11492–11506. doi: 10.18632/oncotarget.3416

Figure 5. MACC1 increases TWIST1/2 transcriptional activity in BGC-823 cells.

Figure 5

(A) Luciferase activity assays in 293T cells showed the enhancement TWIST1 and TWIST2 promoter activity by MACC1. (B) TWIST1 and TWIST2 proteins were silenced by the corresponding siRNA sequences. (C) Representative images of VM density (tube formation) after 24 hours of treatment and the time course of VM density in 3D-cultures of BGC-823 cells treated with silenced TWIST1 or TWIST2, or with the siCTR control. *p < 0.05; **p < 0.01, n = 3 in each group.