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. 2015 Mar 20;6(13):11492–11506. doi: 10.18632/oncotarget.3416

Figure 6. HGF/c-Met contributes to MACC1-induced VM in BGC-823 cells.

Figure 6

(A) Nuclear expression of TWIST1 and TWIST2 was upregulated by recombinant human hepatocyte growth factor (rhHGF), while this change was antagonized by co-treatment with a c-Met inhibitor (PF-04217903). *p < 0.05; **p < 0.01, n = 3 in each group. (B) Effect of rhHGF and PF-04217903 on VM. Representative pictures were taken after 24 hours of treatment with the indicated agents. Scale bar = 50 μm. Effect of rhHGF, rhHGF+PF-04217903, or the vehicle on the VM density over time. *p < 0.05; **p < 0.01, n = 3 in each group. The concentrations of rhHGF and PF-04217903 were 20 μM and 22 μM, respectively.