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. 2015 Mar 23;6(13):11627–11639. doi: 10.18632/oncotarget.3435

Figure 6. Dual inhibition of EGFR and c-MET by ψ-Bufarenogin in HCC.

Figure 6

(A) Binding model of ψ-Bufarenogin in the dimerization pocket of EGFR or c-MET. The position of hydrogen bonds between ψ-Bufarenogin (purple) and EGFR or c-MET was indicated. (B) The effect of ψ-Bufarenogin on the phosphorylation EGFR and c-MET in hepatoma cells was determined by western blot assay. (C) Western blot assay of EGFR and c-MET in addition to their downstream signaling molecules in EGF/HGF-stimulated SMMC-7721 cells pretreated with ψ-Bufarenogin. (D) A schematic representation of the mechanism underlying the inhibitory role of ψ-Bufarenogin against HCC progression.