Table 3. Prognostic value of initial and recurrent factors for progresson-free survival (PFS) and overall survival (OS) at initial diagnosis and recurrence.
| Factors at initial diagnosis | p value | Multivariate (p; HR) | p value | Multivariate (p; HR) |
|---|---|---|---|---|
| Initial PFS | Initial OS | |||
| VEGFR2 | 0,003 | 0,009* HR = 4,119 (1,432–11,846) | 0,02* | 0,019* HR = 3,650 (1,233–10,801) |
| HIF1α | 0,009 | 0,005* HR = 0,275 (0,111–0,679) | 0,011 | 0,012* HR = 0,300 (0,117–0,767) |
| CXCL12 | 0,122 | 0,262 | ||
| CXCR4 | 0,016 | 0,012* HR = 0,303 (0,119–0,770) | 0,290 | 0,180* |
| VEGFA | 0,190 | 0,957 | ||
| VEGFR1 | 0,337 | 0,809 | ||
| AM | 0,413 | 0,416 | ||
| uPA | 0,026 | 0,032* HR = 0.349 (0,133–0,914) | 0,530 | |
| Factors at recurrence | Recurrent PFS | Recurrent OS | ||
| VEGFR2 | 0,022 | 0,020¤ HR = 2,758 (1,177–6,460) | 0,024 | 0,024¤ HR = 2,536 (1,133–5,674) |
| HIF1α | 0,391 | 0,762 | ||
| CXCL12 | 0,589 | 0,639 | ||
| CXCR4 | 0,762 | 0,920 | ||
| VEGFA | 0,032 | 0,026¤ HR = 0,400 (0,178–0,898) | 0,226 | |
| VEGFR1 | 0,050 | 0,045¤ HR = 2,338 (1,019–5,366) | 0,052 | 0,051¤ |
| AM | 0,080 | 0,119 | ||
| Upa | 0,686 | 0,730 | ||
*
Adjusted by Recursive Partitioning Analysis (RPA).
¤
Ajdusted by age and Karnofsky Performans Status (KPS).