Table 2. Association with additional patients characteristics in the Leeds melanoma cohort primaries (N=204).
| Factor | 4-class signature | 2-grade signature | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| High immune (N=44) |
Normal-like (N=69) |
Pigmentation (N=68) |
Proliferative (N=14) |
Unclassified (N=9) |
P a | Low grade (N=88) |
High grade (N=78) |
Unclassified (N=38) |
P a | |
|
Telomere length score (Median, range) |
−0.15 (−0.25, 0.12) |
−0.05 (−0.35, 0.17) |
−0.08 (−0.30, 0.17) |
−0.03 (−0.21, 0.03) |
−0.06 (−0.19, 0.12) |
0.03 | −0.11 (−0.35, 0.12) |
− 0.08 (−0.30, 0.17) |
−0.04 (−0.23, 0.17) |
0.69 |
|
Mole count (Median, range) |
50 (2, 301) |
39 (3, 547) |
39 (0, 226) |
22 (7, 98) |
41 (9, 104) |
0.12 | 43 (2, 465) |
35 (0, 547) |
32 (8, 106) |
0.16 |
|
Sun sensitivity score (Median, range) |
0.06 (−1.43, 1.23) |
−0.11 (−2.00, 1.49) |
−0.12 (−1.86, 1.78) |
0.19 (−0.76, 0.55) |
0.26 (−1.59, 0.88) |
0.87 | −0.03 (−2.00, 1.49) |
−0.07 (1.86, 1.08) |
0.14 (−1.56, 1.78) |
0.56 |
|
Season adjusted vitamin D (Median, range) |
2.0 (−36.1, 39.0) |
−4.2 (−41.9, 43.6) |
−9.1 (−40.7, 31.4) |
−0.8 (−35.4, 29.1) |
−6.0 (−26.5, 19.8) |
0.15 | −4.1 (−39.1, 43.6) |
−8.8 (−41.9, 29.2) |
−2.6 (−39.9, 31.4) |
0.04 |
a
Test ignoring the unclassified samples.