Fig. 1.

Histopathological findings of multiple organs from RV-infected fetuses; the liver shows congestion, expansion of the portal area with inflammatory infiltrate and piecemeal necrosis, vacuolar degeneration of epithelial cells in the intrahepatic bile ducts (a, b), necrotizing and inflammatory changes with apoptotic hepatocytes (so called acidophil bodies; arrows) (c), giant cell formation of hepatocytes (arrows) (d), mild deposition of bile pigments into the hepatocytes (arrows) (e) and erythrophagocytosis by Kupffer cell (inset of e). Mild nephritis with partial hemorrhage in the kidney (f), minor pneumonia accompanied by congestion, alveolar hemorrhage and interstitial edema in the lung (g, h), hypoplasia with hemorrhage in the spleen (i) and lymph node (j), mild myocarditis with interstitial edema in the heart (k) can be seen. H&E stain.