Fig. 2.

Immunohistochemical staining shows distribution of RV capsid antigen in multiple organs. Positive reaction of RV antigen on the surface of hematopoietic mononuclear cells produced in the fetal liver (a, b). Localization of the RV antigen in the epithelial cells of the glomerulus (c) and proximal tubules (d) in the kidney, the epithelial cells of the alveolus (e) and bronchioles (f; inset shows a higher magnification) in the lungs, myocardial cells in the heart (g), spleen cells (h), lymphoid tissue (i), and nerve cells in the cerebral cortex (j). Importantly in the eye, virus antigen was detected in the epithelial cells of the ciliary body (k; red arrows indicates virus antigen and blue arrows indicates melanin pigment cells) and the lachrymal glands (l). The RV capsid antigen is prominent in the cytoplasm of all infected cells. See the text for a more detailed description of these findings.