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. 2014 Dec 2;2(2):172–179. doi: 10.1016/j.ebiom.2014.12.001

Table 1.

Demographic and clinical characteristics of HIV-infected individuals participating in the Amsterdam Cohort Studies included in the study.

Cases
n (%)		 Cases IL13
pos n (%)		 Cases IL13
neg n (%)		 Controls
n (%)		 P-value1 P-value2 P-value3
Total 14 6 8 15
Sex
Male 12 (86) 4 (67) 8 (100) 13 (87) 1.000a 0.544a 0.165a
Female 2 (14) 2 (33) 0 (0) 2 (13)



Age
Years; median (IQR) 38 (33–41) 37 (31–40) 39 (33–44) 37 (35–46) 0.847b 0.622b 0.414b
25–34 5 (36) 2 (33) 3 (38) 3 (20) 0.632a 0.534a 0.627a
35–44 7 (50) 4 (67) 3 (38) 8 (53)
≥ 45 2 (14) 0 (0) 2 (25) 4 (27)



TB classification
PTB 8 (57) 5 (83) 3 (38) 0.096a
EPTB 2 (14) 1 (17) 1 (13)
PTB + EPTB 4 (29) 0 (0) 4 (50)



Sputum smear status
Smear-positive 7 (50) 3 (50) 4 (50) 1.000a
Smear-negative 5 (36) 2 (33) 3 (38)
NA⁎ 2 (14) 1 (17) 1 (13)



Culture status
Positive 12 (86) 5 (83) 7 (88) 1.000a
Negative⁎⁎ 2 (14) 1 (17) 1 (13)



CD4 cell count
Cells per mm3; median (IQR) 270 (168–400) 315 (260–603) 190 (138–325) 340 (220–430) 0.354 b 0.622b 0.081b



Viral load⁎⁎⁎
By p24 ELISA (pg/ml); median (IQR) (n = 17) 18 (0–101) (n = 10) 32 (14–154) (n = 5) 0 (0–56) (n = 5) 0 (0–112) (n = 7) 0.417b 0.106b 0.095b
By RNA (copies/ml); median (IQR) (n = 12) 13,000 (2863–191,250) (n = 4) 11,000 (n = 1)c 150, 15,000, 250,000 (n = 3)c 8300 (400–62,905) (n = 8) 0.932b 1.000b 1.000b



Extent of lung damage on chest X-ray
Mild 4 (29) 2 (33) 2 (25) 0.571a
Moderate 6 (43) 3 (50) 3 (38)
Extensive 2 (14) 0 (0) 2 (25)
NA⁎ 2 (14) 1 (17) 1 (13)



Calendar period of sample (year)
1985–1993 5 (36) 3 (50) 2 (25) 4 (27) 0.791 a 0.311a 0.627a
1994–2002 7 (50) 3 (50) 4 (50) 7 (47)
≥ 2003 2 (14) 0 (0) 2 (25) 4 (27)

P-values represent:

1

Comparison between all TB cases and all controls.

2

Comparison between IL13 positive cases and all controls.

3

Comparison between IL13 positive cases and IL13 negative cases.

a

Tested by Fisher's Exact Test.

b

Tested by Mann–Whitney U test (using exact significance).

c

Numbers too small to calculate median and IQR.

⁎

NA = these represent the 2 TB cases with EPTB; this category was excluded from analysis comparing IL13 positive and IL13 negative cases.

⁎⁎

Both culture negative TB cases responded to treatment.

⁎⁎⁎

A p24 ELISA was done for all cases and controls sampled before 1997, and a RNA test was done for all cases and controls sampled thereafter.