Table 3.
Correlation analyses between the level/activation of the insulin signalling pathway and the levels of O-GlcNAcylation
|
O-GlcNAcylation
|
||
|---|---|---|
| r | p | |
| IRβ | 0.154 | 0.505 |
| IRS-1 | 0.057 | 0.808 |
| PI3K(p85) | 0.081 | 0.727 |
| pPI3K(p85) | 0.362 | 0.107 |
| PDK1 | 0.714 | 0.000 |
| pPDK1 | 0.047 | 0.840 |
| AKT | 0.492 | 0.024 |
| pAKT | 0.049 | 0.833 |
| GSK-3β | 0.269 | 0.239 |
| pGSK-3β(S9) | 0.294 | 0.195 |
The level and activation of each component of the insulin signalling pathway and the level of O-GlcNAcylation in the frontal cortex were determined by quantitative western blots. The r and p values that reach statistical significance (p < 0.05) are printed in bold.