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. Author manuscript; available in PMC: 2016 May 21.
Published in final edited form as: Cell. 2015 May 21;161(5):1215–1228. doi: 10.1016/j.cell.2015.05.001

Figure 6. Aberrations in the WNT pathway found in mCRPC.

Figure 6

A, Cases with aberrations in the WNT pathway. Case numbering as in Fig. 2. B, Aberrations identified in APC and CTNNB1. Amino acids altered are indicated. ARM, armadillo repeat. Phos, phosphorylation domain. TAD, trans-activating domain. EB1, end binding protein-1 domain. CC, coiled coil. C, Outlier expression of RSPO2 in CRPC and the GRHL2-RSPO2 gene fusion. RNA-seq expression across our CRPC cohort. Structure of the gene fusion is inset. UTR, untranslated region. CDS, coding sequence.