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A, Cases with aberrations in the DNA repair pathway. Case numbering as in Fig. 2. B, Aberrations identified in BRCA2, ATM and BRCA1. Amino acids altered are indicated. HELC, helical domain. OB, oligonucleotide binding fold. FAT, FRAP-ATM-TRRAP domain. PIK3c, PI3 kinase domain. CC, coiled coil. BRC, Brca repeat. C, Microsatellite instability analysis of representative hypermutated CRPC cases and non-hypermutated cases.
