Table 1.
Group | Blood glucose (mg/dL) | Plasma insulin (ng/ml) |
---|---|---|
NO Donor vs. Saline | ||
WT + SAL | 104 ± 8 | 1.3 ± 0.4 |
WT + NO | 101 ± 9 | 0.3 ± 0.1* |
LPS vs. Saline; iNOS−/− vs. iNOS+/+ Mice | ||
WT + SAL | 96 ± 5 | 0.7 ± 0.2 |
WT + LPS | 88 ± 6 | 0.7 ± 0.2 |
iNOS KO + SAL | 96 ± 5 | 1.0 ± 0.1 |
iNOS KO + LPS | 83 ± 6** | 0.7 ± 0.3 |
All blood and plasma measurements were sampled 10 min before clamp onset (i.e., t = −10 min). Data are presented as mean ± SEM. *p < 0.05 vs. WT + SAL; **p < 0.05 vs. iNOS KO + SAL. iNOS inducible nitric oxide synthase, KO knock-out, LPS lipopolysaccharide, NO nitric oxide donor (sodium nitroprusside), SAL saline, WT wild-type