Table 2.

Impact of LPS on inflammatory gene expression in WT and iNOS KO mice

Group	Heart	Gastrocnemius
Interleukin-6 gene expression
WT + SAL	1.5 ± 0.9	1.4 ± 0.8
WT + LPS	9.6 ± 3.2p = 0.07	61 ± 26*
iNOS KO + SAL	4.1 ± 2.3	1.4 ± 0.6
iNOS KO + LPS	19.6 ± 4.7**	9.5 ± 0.9***
Monocyte Chemoattractant Protein-1 (MCP)-1 gene expression
WT + SAL	1.1 ± 0.4	1.1 ± 0.3
WT + LPS	2.6 ± 0.1*	4.9 ± 2.1
iNOS KO + SAL	1.8 ± 0.7	0.6 ± 0.6
iNOS KO + LPS	6.1 ± 2.1 p = 0.07	12.1 ± 5.3**

Relative expression (R_q) of Interleukin-6 and Monocyte Chemoattractant Protein-1 (MCP-1) gene measured in tissues excised at the end of a hyperinsulinemic-euglycemic clamp. Data are R_q values relative to the control group (WT + SAL). Data are mean ± SEM. *p < 0.05 vs. WT + SAL; **p < 0.05 vs. iNOS KO + SAL; ***p < 0.05 vs. WT + LPS. iNOS inducible nitric oxide synthase, KO knock-out, LPS lipopolysaccharide, SAL saline, WT wild-type