Table 2.
Previously reported associations replicated in the meta-analysis
| All cases | ER-negative cases | ER-positive cases | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Published | Model | Effect allele | Effect allele freq | HR (90% CI) | One-sided | HR (90% CI) | One-sided | HR (90% CI) | One-sided |
| P value | P value | P value | |||||||||
| rs2981582 | FGFR2 | Bayraktar et al. [34] | Dominance | G | 0.57 | 1.09 (1.04-1.14) | 0.00085 | 1.08 (1.00-1.16) | 0.052 | 1.04 (0.98-1.10) | 0.15 |
| rs1800566 | NQO1 | Fagerholm et al. [14] | Dominance | A | 0.19 | 1.10 (1.03-1.17) | 0.0046 | 1.14 (1.03-1.25) | 0.015 | 1.04 (0.95-1.13) | 0.23 |
| rs9934948 | LOC100506172 | Shu et al. [6] (GWAS) | Co-dominance | T | 0.15 | 0.92 (0.86-0.98) | 0.011 | 0.90 (0.79-1.01) | 0.059 | 0.95 (0.86-1.04) | 0.18 |
| rs1800470 | TGF | Shu et al. [6] | Co-dominance | A | 0.61 | 0.95 (0.91-0.99) | 0.030 | 0.96 (0.88-1.04) | 0.20 | 0.95 (0.88-1.02) | 0.12 |
| rs3775775 | SULT1E1 | Choi et al. [47] | Dominance | G | 0.09 | 1.08 (1.00-1.16) | 0.046 | 1.17 (1.03-1.31) | 0.02 | 1.06 (0.95-1.17) | 0.18 |
| rs700519 | CYP19A1 | Long et al. [55] | Dominance | A | 0.03 | 1.10 (0.98-1.22) | 0.093 | 1.03 (0.83-1.23) | 0.40 | 1.30 (1.10-1.50) | 0.0050 |
| rs731236 | VDR | Perna et al. [66] | Co-dominance | G | 0.39 | 1.04 (1.00-1.08) | 0.056 | 1.03 (0.95-1.11) | 0.28 | 1.09 (1.02-1.16) | 0.017 |
| rs12900137 | CYP19A1 | Long et al. [55] | Dominance | C | 0.05 | 1.01 (0.91-1.11) | 0.47 | 0.94 (0.78-1.10) | 0.70 | 1.18 (1.02-1.34) | 0.032 |
| rs10477313 | PPP2R2B | Jamshidi et al. [35] | Dominance | T | 0.12 | 0.94 (0.87- 1.01) | 0.08 | 0.92 (0.79-1.05) | 0.15 | 0.88 (0.77-0.99) | 0.035 |
| rs2333227 | MPO | Ambrosone et al. [45] | Dominance | T | 0.21 | 1.03 (0.97-1.09) | 0.20 | 0.95 (0.87-1.03) | 0.78 | 1.09 (1.01-1.17) | 0.036 |
| rs1902586 | CYP19A1 | Long et al. [55] | Dominance | A | 0.05 | 1.01 (0.91-1.11) | 0.44 | 0.99 (0.83-1.15) | 0.54 | 1.16 (1.01-1.31) | 0.041 |
| rs28566535 | CYP19A1 | Long et al. [55] | Dominance | C | 0.05 | 1.00 (0.90-1.10) | 0.51 | 0.97 (0.81-1.13) | 0.60 | 1.15 (1.00-1.30) | 0.046 |
Hazard ratios are for breast cancer-specific survival using a Cox proportional hazards model corrected for principal components; hazard ratios, confidence intervals and P values are from a co-dominant model; P values refer to a one-sided test of association in the direction indicated in bold in the 90% CI of the HR; P values in bold indicate results that are nominally significant (P <0.05). HR, hazard ratio; CI, confidence interval; GWAS, genome-wide association study.