Table 1.
Demographic and Lifestyle Characteristics of Mothers, Exposed and Unexposed to Venlafaxine During Early Pregnancy, National Birth Defects Prevention Study, 1997–2007
| Used Venlafaxine (n=91) |
Unexposed (n=26,954) |
P-value | |||
|---|---|---|---|---|---|
| n | % | n | % | ||
| Age | |||||
| <30 years | 48 | 52.8 | 16344 | 60.6 | 0.12 |
| ≥ 30 years | 43 | 47.2 | 10610 | 39.4 | |
| Education | |||||
| ≤High School | 19 | 20.9 | 11594 | 43.0 | <0.01 |
| >High School | 72 | 79.1 | 15107 | 56.0 | |
| Missing | 253 | 0.9 | |||
| Race | |||||
| NH White | 83 | 91.2 | 15778 | 58.5 | <0.01 |
| Other | 8 | 8.8 | 11167 | 41.4 | |
| Missing | 9 | 0.0 | |||
| Obesity1 | |||||
| Yes | 23 | 25.3 | 4558 | 16.9 | 0.06 |
| No | 68 | 74.7 | 21171 | 78.5 | |
| Missing | 1225 | 4.5 | |||
| Smoking2 | |||||
| Any | 21 | 23.1 | 5150 | 19.1 | 0.35 |
| None | 70 | 76.9 | 21612 | 80.2 | |
| Missing | 192 | 0.7 | |||
| Alcohol2 | |||||
| Any | 39 | 42.9 | 9678 | 35.9 | 0.19 |
| None | 52 | 57.1 | 16986 | 63.0 | |
| Missing | 290 | 1.1 | |||
| Folic Acid Use3 | |||||
| Any | 67 | 73.6 | 13477 | 50.0 | <0.01 |
| None | 24 | 26.4 | 13477 | 50.0 | |
| Parity | |||||
| No previous live birth | 32 | 35.2 | 11338 | 42.1 | 0.18 |
| At least 1 previous live birth | 59 | 64.8 | 15585 | 57.8 | |
| Missing | 31 | 0.1 | |||
| Estimated Date of Delivery | |||||
| 1997 | 0 | 0 | 308 | 1.1 | <.01 |
| 1998 | 2 | 2.2 | 2359 | 8.8 | |
| 1999 | 1 | 1.1 | 2769 | 10.3 | |
| 2000 | 5 | 5.5 | 2946 | 10.9 | |
| 2001 | 3 | 3.3 | 2725 | 10.1 | |
| 2002 | 11 | 12.1 | 2385 | 8.9 | |
| 2003 | 6 | 6.6 | 2591 | 9.6 | |
| 2004 | 19 | 20.9 | 3020 | 11.2 | |
| 2005 | 17 | 18.7 | 2825 | 10.5 | |
| 2006 | 12 | 13.2 | 2509 | 9.3 | |
| 2007 | 15 | 16.5 | 2517 | 9.3 | |
| Study Centers | |||||
| Arkansas | 16 | 17.6 | 3515 | 13.0 | <.01 |
| California | 7 | 7.7 | 3505 | 13.0 | |
| Georgia/CDC | 7 | 7.7 | 3062 | 11.4 | |
| Iowa | 16 | 17.6 | 2601 | 9.7 | |
| Massachusetts | 9 | 9.9 | 3451 | 12.8 | |
| New Jersey | 1 | 1.1 | 1957 | 7.3 | |
| New York | 5 | 5.5 | 2048 | 7.6 | |
| North Carolina | 5 | 5.5 | 1561 | 5.8 | |
| Texas | 6 | 6.6 | 3232 | 12.0 | |
| Utah | 19 | 20.9 | 2022 | 7.5 | |
1
Obesity is defined as a body mass index greater than or equal to 30 and is based on self-reported height and weight.
2
1 month prior to pregnancy through third month of pregnancy
3
1 month prior to pregnancy through first month of pregnancy