Table 3.
Association between use of venlafaxine just before and during early pregnancy and the occurrence of certain birth defects, National Birth Defects Prevention Study, Restricted to 2003–2007
| Birth Defects | Total | Exposed | Crude Odds Ratio (Exact 95% CI) |
|---|---|---|---|
| No Major Birth Defects (Control Infants) | 4038 | 12 | 1.0 (ref) |
| Anencephaly | 210 | 4 | 6.5 (1.5–21.7) |
| SpinaBifida | 431 | 2 | § |
| Anotia or Microtia | 216 | 1 | § |
| Contruncal Heart Defects | 826 | 3 | 1.2 (0.2–4.5) |
| D-Transposition of the Great Arteries | 254 | 2 | § |
| Tetralogy of Fallot | 388 | 0 | § |
| Septal Heart Defects | 1795 | 11 | 2.1 (0.8–5.1) |
| Perimembranous Ventricular Septal Defect | 659 | 4 | 2.0 (0.5–6.8) |
| Atrial Septal Defect type 2 or not otherwise specified | 1221 | 6 | 1.7 (0.5–4.8) |
| Ventricular Septal Defect-Atrial Septal Defect Association | 308 | 1 | § |
| Right Ventricular Outflow Tract Obstruction Defects1 | 669 | 3 | 1.5 (0.3–5.6) |
| Pulmonary Valve Stenosis | 543 | 3 | 1.9 (0.3–6.9) |
| Left Ventricular Outflow Tract Obstruction Defects | 790 | 7 | 3.0 (1.0–8.3) |
| Hypoplastic Left Heart Syndrome | 220 | 2 | § |
| Coarctation of the Aorta | 427 | 4 | 3.2 (0.7–10.5) |
| Cleft Lip with or without Cleft Palate | 1036 | 5 | 1.6 (0.4–4.8) |
| Cleft Palate alone | 522 | 5 | 3.1 (0.9–9.6) |
| AnorectalAtresia | 344 | 1 | § |
| Esophageal Atresia | 215 | 0 | § |
| Hypospadias, 2nd/3rd degree2 | 777 | 6 | 3.2 (0.8–13.5) |
| Any Limb Reduction Defect | 385 | 3 | 2.6 (0.5–9.8) |
| Craniosynostosis | 574 | 2 | § |
| Diaphragmatic Hernia | 305 | 1 | § |
| Gastroschisis | 508 | 5 | 3.3 (0.9–10.2) |
§
Two or fewer exposed cases; No odds ratios calculated.
1
Excluding Ebstein’s Anomaly
2
Hypospadias among male infants only; 2089control male infants