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. Author manuscript; available in PMC: 2015 Jun 29.
Published in final edited form as: Expert Opin Ther Targets. 2015 Mar 13;19(6):835–847. doi: 10.1517/14728222.2015.1018181

Figure 5. Three types of TSHR-Abs.

Figure 5

The receptor stimulating antibodies and blocking antibodies as described bind to the leucine-rich domain in the ectodomain. Stimulating antibody lead to activation of Gs and cAMP, whereas the blocking antibodies inhibit TSH from binding. The neutrals bind to the ‘hinge region’ of the receptor and are capable of MAPK signaling. We have made three different types of hamster mAbs to the TSHR. Stimulating antibody binds with the TSHR ectodomain, whereas the neutral variety recognizes hinge region. We are interested to study their vesicular trafficking and signaling.

TSHR: Thyroid-stimulating hormone receptor.