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. Author manuscript; available in PMC: 2015 Jun 29.
Published in final edited form as: Expert Opin Ther Targets. 2015 Mar 13;19(6):835–847. doi: 10.1517/14728222.2015.1018181

Table 2.

Small molecule ligand agonists to the TSHR.

Small molecule ligands Chemical name Action EC50/IC50 Binding site Ref.
Org 41841 N-tert-Butyl-5-amino-4-(3-methoxy-phenyl)-2-(methylthio)thieno[2,3-d] pyrimidine-6-carboxamide Partial Agonist 7.7 × 10−6 (7700 nM) TM3,4,5,6 & 7 [58]
NCG00161870 N-4 (4-(5-(3-benzyl-5-hydrooxy-4-ox0-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)acetamide Agonist 4 × 10−8 M (40 nM) TM5 [59]
MS437 N,N-diisopropyl-2-phenyl-4 quinolinecarboxamide Agonist 1.3 × 10−7 M TM3 [60]
MS438 Benzyl6methyl-2-oxo-4-[4-(trifluorome-thyl0phenyl]-1,2,3,4-tetrahydro-5-pyrimidinevarboxylate Agonist 5.3 × 10−8 M TM3 [60]

TSHR: Thyroid-stimulating hormone receptor.