Table 2.
Small molecule ligands | Chemical name | Action | EC50/IC50 | Binding site | Ref. |
---|---|---|---|---|---|
Org 41841 | N-tert-Butyl-5-amino-4-(3-methoxy-phenyl)-2-(methylthio)thieno[2,3-d] pyrimidine-6-carboxamide | Partial Agonist | 7.7 × 10−6 (7700 nM) | TM3,4,5,6 & 7 | [58] |
NCG00161870 | N-4 (4-(5-(3-benzyl-5-hydrooxy-4-ox0-1,2,3,4-tetrahydroquinazolin-2-yl)-2-methoxybenzyloxy)acetamide | Agonist | 4 × 10−8 M (40 nM) | TM5 | [59] |
MS437 | N,N-diisopropyl-2-phenyl-4 quinolinecarboxamide | Agonist | 1.3 × 10−7 M | TM3 | [60] |
MS438 | Benzyl6methyl-2-oxo-4-[4-(trifluorome-thyl0phenyl]-1,2,3,4-tetrahydro-5-pyrimidinevarboxylate | Agonist | 5.3 × 10−8 M | TM3 | [60] |
TSHR: Thyroid-stimulating hormone receptor.