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Islet-associated macrophages in the progression of T2D: the knowns and unknowns. The pathogenesis of T2D is a complex process, but islet macrophages are emerging as significant regulators of the islet inflammatory milieu at various nodes during the progression of T2D. Although a number of studies highlighted in this review have provided key insight into islet macrophage biology, several important questions remain. Refer to the text for additional discussion.
